GcMAF Forte

Clinical application of GcMAF Forte

Introduction to GcMAF Forte

Gc protein-derived Macrophage Activating Factor.

  • What are macrophages?
  • What is GcMAF Forte?
  • GcMAF-Forte
  • No Side Effects
  • Contains No Human Materials
  • What’s new on GcMAF Forte therapy?
  • 10.000ng - once a week treatment
  • How is GcMAF Forte used?
  • Cancer
  • Infectious diseases
  • Hair regrowth
  • Allergies
  • Chronic fatigue syndrome (CFS)
  • Multiple sclerosis (MS)
  • Rheumatoid arthritis (RA)
GcMAF-Forte

Macrophage morphology - GcMAF Forte

  • Macrophages are hungry white blood cells
  • They engulf invading bacteria and target cells
  • Move like amoebas
  • Found in essentially all tissues
Macrophange and Dentric Cell
Adherent macrophage
Adherent macrophage

Macrophage functions - GcMAF Forte

  • Phagocytosis: Detecting, engulfing and destroying pathogens
  • Removal of dying or dead cells and cellular debris
  • Scavenging worn-out cells and other debris
  • Critical role in adaptive immunity
  • Wound healing, tissue repair and regeneration
A macrophage
A macrophage

Macrophage phagocytosis - GcMAF Forte

Steps of a macrophage ingesting a pathogen by phagocytosis.
Steps of a macrophage ingesting a pathogen by phagocytosis.
Phagocytosis assay with Second Generation GcMAF. Arrows indicate cells internalized by macrophages.
Phagocytosis assay with Second Generation GcMAF. Arrows indicate cells internalized by macrophages.

Tissue macrophages - GcMAF Forte

Immi24
  • Macrophages exist in nearly all tissues
  • Tissue resident macrophages play critical roles in repair and regeneration of each tissue

Macrophage activation steps

Institute of applied technology for innate immunity, Kagawa University
Institute of applied technology for innate immunity, Kagawa University
  • Triggered state: Macrophages are fighting against pathogens, producing cytokines
  • Primed state: Macrophages are “getting ready” against pathogens, without producing cytokines
  • Aged, stressed state: Macrophages are not getting ready, even if pathogensareinvading thebody

GcMAF Forte Therapy

GcMAF Forte
  • Developed for IMMI
  • High concentration (10.000 ng/2 ml, 1 dose)
  • Significantly higher stability and macrophage activating activity
  • Sterilization process using non- human material
  • New patented product
GcMAF Forte
GcMAF Forte

Gut immunity and new findings - GcMAF Forte

  • Gut bacteria have an intricate relationship with our immune system
  • They play a critical role in training immune cells
  • Important to the development of immune cells, known as T helper 17 cells
  • The bacterium Prevotella copri was present in 75% of rheumatoid arthritis patients, causing inflammation in the gut
  • Gut bacteria may be linked to allergy, obesity, rheumatoidarthritisandautoimmunediseases

Targeting the Blood-Brain Barrier - GcMAF Forte

  • The advent of two-photon microscopy made it possible to watch the blood-brain barrier in a living, breathing mouse
  • Microglia are resident macrophages that patrol the brain and spinal cord for damaged cells and infectious agents
  • Microglia also may protect and repair the blood-brain barrier as tight junctions
  • Malfunctioning microglia could lead to a wide variety of neurodegenerative diseases, from Alzheimer’s to Parkinson’s
  • Multiple Sclerosis (MS) is caused by the breakdown of myelin, a rubbery sheath of neurons
  • MRI studies suggest breaches in the blood-brain barrier precipitate MS attacks, allowing too many white blood cells to cross the blood-brain barrier, attacking the myelin

Neurosurgeons’ group at Tokushima University demonstrated through extensive research that GcMAF can effectively activate microglia in the brain. Using an advanced mice model of cerebral infarction, they observed significant neural restoration, reduced inflammation, and improved microglial functionality, indicating promising potential therapeutic applications for brain injuries and neurodegenerative diseases.

ScientificAmerican,June2013

Commonly observed clinical effects GcMAF Forte

  • Improvedsleep, moreenergy;reducedfatigue
  • Improved digestion, reduced nocturnal urination
  • Improved hair regrowth and reduced hair loss due to natural ageing
  • Improved skin condition & smoothness
  • Improved control or curing of infectious diseases such as virus, bacteria and other pathogens
  • Reduced allergy symptoms, pollinosis and atopy

Current indications for GcMAF

  • Various infectious diseases
  • – Manyacuteinfectiousdiseases
  • – Manychronic infectiousdiseases
  • Cancer
  • Multiple sclerosis (MS)
  • Rheumatoid arthritis (RA)
  • Lyme disease
  • Chronic fatiguesyndrome(CFS)
  • Autism
  • Autoimmune diseases
  • Alopecia, hair loss
  • Atopic dermatitis
  • Pollinosis
  • Skin rejuvenation (repair, anti-aging effects)
  • Psoriasis
Malaria parasite
Malaria parasite
Ebola virus
Ebola virus
Influenza virus
Influenza virus

New possible indications for GcMAF

  • Alzheimer’s disease
  • Dementia
  • Brain degenerative disease, such as Parkinson’s disease
  • Epilepsy
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Gc protein-derived Macrophage Activating Factor
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