Phagocytosis: Detecting, engulfing and destroying pathogens
Removal of dying or dead cells and cellular debris
Scavenging worn-out cells and other debris
Critical role in adaptive immunity
Wound healing, tissue repair and regeneration
Macrophage phagocytosis
Tissue macrophages
Macrophages exist in nearly all tissues
Tissue resident macrophages play critical roles in repair and regeneration of each tissue
Macrophage activation steps
Triggered state: Macrophages are fighting against pathogens, producing cytokines
Primed state: Macrophages are “getting ready” against pathogens, without producing cytokines
Aged, stressed state: Macrophages are not getting ready, even if pathogensareinvading thebody
GcMAF Forte Therapy
GcMAF Forte
Developed for IMMI
High concentration (10.000 ng/2 ml, 1 dose)
Significantly higher stability and macrophage activating activity
Sterilization process using non- human material
New patented product
Gut immunity and new findings
Gut bacteria have an intricate relationship with our immune system
They play a critical role in training immune cells
Important to the development of immune cells, known as T helper 17 cells
The bacterium Prevotella copri was present in 75% of rheumatoid arthritis patients, causing inflammation in the gut
Gut bacteria may be linked to allergy, obesity, rheumatoidarthritisandautoimmunediseases
Targeting the Blood-Brain Barrier
The advent of two-photon microscopy made it possible to watch the blood-brain barrier in a living, breathing mouse
Microglia are resident macrophages that patrol the brain and spinal cord for damaged cells and infectious agents
Microglia also may protect and repair the blood-brain barrier as tight junctions
Malfunctioning microglia could lead to a wide variety of neurodegenerative diseases, from Alzheimer’s to Parkinson’s
Multiple Sclerosis (MS) is caused by the breakdown of myelin, a rubbery sheath of neurons
MRI studies suggest breaches in the blood-brain barrier precipitate MS attacks, allowing too many white blood cells to cross the blood-brain barrier, attacking the myelin
Neurosurgeons’ group at Tokushima University showed that GcMAF can activate microglia in the brain using a mice model of cerebral infarction
Commonly observed clinical effects
GcMAF Forte
Improvedsleep, moreenergy;reducedfatigue
Improved digestion, reduced nocturnal urination
Improved hair regrowth and reduced hair loss due to natural ageing
Improved skin condition & smoothness
Improved control or curing of infectious diseases such as virus, bacteria and other pathogens
Reduced allergy symptoms, pollinosis and atopy
Current indications for GcMAF
Various infectious diseases
– Manyacuteinfectiousdiseases
– Manychronic infectiousdiseases
Cancer
Multiple sclerosis (MS)
Rheumatoid arthritis (RA)
Lyme disease
Chronic fatiguesyndrome(CFS)
Autism
Autoimmune diseases
Alopecia, hair loss
Atopic dermatitis
Pollinosis
Skin rejuvenation (repair, anti-aging effects)
Psoriasis
New possible indications for GcMAF
Alzheimer’s disease
Dementia
Brain degenerative disease, such as Parkinson’s disease